Parathyroid hormone-related protein (PTH-rP)-associated hypercalcemia in a patient with an atypical chronic lymphocytic leukemia

Neth J Med. 1999 Jan;54(1):21-6. doi: 10.1016/s0300-2977(98)00099-0.

Abstract

We describe a patient with an atypical chronic lymphocytic leukemia (CLL) of the mixed cell type with a hypercalcemia due to parathyroid hormone-related protein production by the malignant B cells. On regard of the elevated serum calcium level without overt lytic bone lesions we found elevated serum levels of PTH-rP and demonstrated the presence of PTH-rP on the malignant lymphocytes. PTH-rP-related hypercalcemia in CLL is very rare. The role in PTH-rP in humoral hypercalcemia of malignancy is discussed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cyclophosphamide / administration & dosage
  • Fatal Outcome
  • Humans
  • Hypercalcemia / blood*
  • Hypercalcemia / etiology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / blood
  • Leukemia, Lymphocytic, Chronic, B-Cell / complications*
  • Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
  • Male
  • Parathyroid Hormone / blood*
  • Parathyroid Hormone-Related Protein
  • Peptide Fragments / blood*
  • Prednisone / administration & dosage
  • Proteins*
  • Sepsis
  • Vincristine / administration & dosage

Substances

  • PTHLH protein, human
  • Parathyroid Hormone
  • Parathyroid Hormone-Related Protein
  • Peptide Fragments
  • Proteins
  • parathyroid hormone-related protein (107-111)
  • Vincristine
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • COP protocol 2