Abstract
We describe a patient with an atypical chronic lymphocytic leukemia (CLL) of the mixed cell type with a hypercalcemia due to parathyroid hormone-related protein production by the malignant B cells. On regard of the elevated serum calcium level without overt lytic bone lesions we found elevated serum levels of PTH-rP and demonstrated the presence of PTH-rP on the malignant lymphocytes. PTH-rP-related hypercalcemia in CLL is very rare. The role in PTH-rP in humoral hypercalcemia of malignancy is discussed.
MeSH terms
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cyclophosphamide / administration & dosage
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Fatal Outcome
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Humans
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Hypercalcemia / blood*
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Hypercalcemia / etiology*
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Leukemia, Lymphocytic, Chronic, B-Cell / blood
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Leukemia, Lymphocytic, Chronic, B-Cell / complications*
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Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
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Male
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Parathyroid Hormone / blood*
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Parathyroid Hormone-Related Protein
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Peptide Fragments / blood*
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Prednisone / administration & dosage
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Proteins*
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Sepsis
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Vincristine / administration & dosage
Substances
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PTHLH protein, human
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Parathyroid Hormone
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Parathyroid Hormone-Related Protein
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Peptide Fragments
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Proteins
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parathyroid hormone-related protein (107-111)
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Vincristine
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Cyclophosphamide
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Prednisone