Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type

M Yamamoto-Sasaki; H Ozawa; T Saito; M Rösler; P Riederer

doi:10.1016/s0006-8993(99)01220-2

Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type

Brain Res. 1999 Apr 10;824(2):300-3. doi: 10.1016/s0006-8993(99)01220-2.

Authors

M Yamamoto-Sasaki¹, H Ozawa, T Saito, M Rösler, P Riederer

Affiliation

¹ Clinical Neurochemistry, Department of Psychiatry, University of Würzburg, Füchsleinstrasse 15, 97080, Würzburg, Germany. megumi.sasaki@mail.uni-wuerzburg.de

PMID: 10196463
DOI: 10.1016/s0006-8993(99)01220-2

Abstract

Cyclic AMP (cAMP) is disrupted in the brain in dementia of the Alzheimer type (DAT). We investigated whether the cAMP reduction is accompanied by an alteration in the cAMP response element binding protein (CREB) downstream in DAT and control hippocampi. Immunoreactivity of pCREB was significantly decreased in DAT, while total CREB level was unchanged. These findings indicate that impaired cAMP signaling may contribute to the pathophysiology of the disease.

Publication types

Clinical Trial
Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Alzheimer Disease / metabolism*
Cyclic AMP Response Element-Binding Protein / metabolism*
Female
Hippocampus / metabolism*
Humans
Linear Models
Male
Middle Aged
Nerve Tissue Proteins / metabolism*
Phosphorylation

Substances

Cyclic AMP Response Element-Binding Protein
Nerve Tissue Proteins