Role of red blood cells in pharmacokinetics of chemotherapeutic agents

Anticancer Drugs. 1999 Feb;10(2):147-53. doi: 10.1097/00001813-199902000-00002.

Abstract

After oral or parenteral administration of chemotherapeutic agents, these drugs are transported to the tissues by the blood in different fractions: plasma water, plasma proteins or cells. In this review, the role of the red blood cell in storage, transport and metabolism of different anti-cancer drugs is described.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Anthracyclines / blood
  • Antibiotics, Antineoplastic / blood
  • Antineoplastic Agents / blood*
  • Antineoplastic Agents / pharmacokinetics
  • Asparaginase / blood
  • Asparaginase / pharmacokinetics
  • Asparaginase / toxicity
  • Doxorubicin / blood
  • Epirubicin / blood
  • Erythrocytes / drug effects
  • Erythrocytes / metabolism*
  • Fluorouracil / blood
  • Humans
  • Ifosfamide / blood
  • Infusions, Parenteral
  • Mercaptopurine / blood
  • Methotrexate / blood
  • Paclitaxel / blood
  • Platinum Compounds / pharmacokinetics

Substances

  • Anthracyclines
  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Platinum Compounds
  • Epirubicin
  • Doxorubicin
  • Mercaptopurine
  • Asparaginase
  • Paclitaxel
  • Fluorouracil
  • Ifosfamide
  • Methotrexate