Abstract
ITIM-bearing molecules represent a novel family of inhibitory receptors expressed widely through the hematopoietic compartment. These molecules share certain features such as the presence in their intracytoplasmic domain of the so-called motif ITIM (ImmunoTyrosine-based Inhibition Motif). These molecules are able to recruit phosphatases on their phosphorylated ITIM and thus mediate a localized inhibition of the transduction pathways. The molecular basis of this inhibitory pathway is discussed below.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Humans
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Immunoglobulins / chemistry
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Immunoglobulins / metabolism*
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Lectins / chemistry
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Lectins / metabolism*
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Lymphocyte Activation*
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Mice
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Models, Biological
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Molecular Sequence Data
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Phosphorylation
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Protein Tyrosine Phosphatases / chemistry
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Protein Tyrosine Phosphatases / metabolism*
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Receptors, Immunologic / chemistry
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Receptors, Immunologic / metabolism*
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Tyrosine / metabolism
Substances
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Immunoglobulins
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Lectins
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Receptors, Immunologic
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Tyrosine
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Protein Tyrosine Phosphatases