Abstract
Disruption of the IL-4 gene in two inbred mouse strains revealed a dual role of IL-4 in Staphylococcus aureus sepsis and arthritis depending on the host's genetic background. IL-4 was protective in 129SV mice, since 5 days after S. aureus inoculation IL-4(-/-) mice displayed 70% mortality as compared to survival of all 129SV wild-type counterparts. On the other hand, IL-4 was detrimental in C57BL/6 mice, since survival of IL-4(-/-) C57BL/6 mice was increased, as compared to wild-type controls, due to decreased staphylococcal growth. Altogether, our results show the dual role of IL-4 in S. aureus sepsis and arthritis, depending on the genetic background of the host.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Bacterial / blood
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Arthritis, Infectious / etiology*
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Arthritis, Infectious / genetics
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Arthritis, Infectious / immunology
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Cytotoxicity, Immunologic
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Female
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Immunoglobulin G / blood
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Interferon-gamma / biosynthesis
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Interleukin-4 / biosynthesis
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Interleukin-4 / deficiency*
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Interleukin-4 / genetics
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Macrophages / immunology
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Male
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Mice
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Mice, Inbred C57BL
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Mice, Inbred Strains
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Mice, Knockout
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Sepsis / etiology*
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Sepsis / genetics
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Sepsis / immunology
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Species Specificity
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Staphylococcal Infections / etiology*
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Staphylococcal Infections / genetics
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Staphylococcal Infections / immunology
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Staphylococcus aureus / pathogenicity
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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Antibodies, Bacterial
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Immunoglobulin G
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Tumor Necrosis Factor-alpha
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Interleukin-4
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Interferon-gamma