The interaction between RTX toxins and target cells

Trends Microbiol. 1999 Sep;7(9):356-61. doi: 10.1016/s0966-842x(99)01530-9.

Abstract

RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They fall into two categories: the hemolysins, which affect a variety of cell types, and the leukotoxins, which are cell-type- and species-specific. These toxins offer interesting models for targeting, insertion and translocation of aqueous proteins into lipid membranes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Bacterial Toxins / chemistry
  • Bacterial Toxins / metabolism*
  • Bacterial Toxins / toxicity
  • Cell Membrane / metabolism*
  • Cytotoxins / chemistry
  • Cytotoxins / metabolism*
  • Cytotoxins / toxicity
  • Exotoxins / chemistry
  • Exotoxins / metabolism
  • Exotoxins / toxicity
  • Gram-Negative Bacteria / metabolism*
  • Hemolysin Proteins / chemistry
  • Hemolysin Proteins / metabolism*
  • Hemolysin Proteins / toxicity
  • Humans
  • Necrosis

Substances

  • Bacterial Toxins
  • Cytotoxins
  • Exotoxins
  • Hemolysin Proteins
  • leukotoxin