Abstract
RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria. They fall into two categories: the hemolysins, which affect a variety of cell types, and the leukotoxins, which are cell-type- and species-specific. These toxins offer interesting models for targeting, insertion and translocation of aqueous proteins into lipid membranes.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Apoptosis
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Bacterial Toxins / chemistry
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Bacterial Toxins / metabolism*
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Bacterial Toxins / toxicity
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Cell Membrane / metabolism*
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Cytotoxins / chemistry
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Cytotoxins / metabolism*
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Cytotoxins / toxicity
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Exotoxins / chemistry
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Exotoxins / metabolism
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Exotoxins / toxicity
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Gram-Negative Bacteria / metabolism*
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Hemolysin Proteins / chemistry
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Hemolysin Proteins / metabolism*
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Hemolysin Proteins / toxicity
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Humans
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Necrosis
Substances
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Bacterial Toxins
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Cytotoxins
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Exotoxins
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Hemolysin Proteins
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leukotoxin