Pulmonary toxoplasmosis in bone marrow transplant recipients: report of two cases and review

Clin Infect Dis. 1999 Aug;29(2):429-33. doi: 10.1086/520228.

Abstract

Toxoplasma gondii may cause disseminated disease in bone marrow transplant (BMT) recipients. Pulmonary toxoplasmosis in BMT patients is rarely described. Mortality rates of >90% have been previously reported. Since pulmonary toxoplasmosis is extremely difficult to diagnose, it is very often detected only at autopsy. Two cases of pulmonary toxoplasmosis in BMT recipients that were diagnosed by visualization of T. gondii tachyzoites in bronchoalveolar lavage fluid and by a new semi-nested PCR method amplifying 18S rRNA from bronchoalveolar lavage fluid are presented, and the literature on pulmonary toxoplasmosis in BMT patients is reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Animals
  • Bone Marrow Transplantation / adverse effects*
  • Bronchoalveolar Lavage Fluid / parasitology
  • DNA, Protozoan / analysis
  • Fatal Outcome
  • Female
  • Humans
  • Lung Diseases, Parasitic / etiology*
  • Lung Diseases, Parasitic / pathology
  • Middle Aged
  • Toxoplasma* / genetics
  • Toxoplasma* / isolation & purification
  • Toxoplasma* / ultrastructure
  • Toxoplasmosis / diagnosis
  • Toxoplasmosis / etiology*
  • Toxoplasmosis / pathology

Substances

  • DNA, Protozoan