A toxic extract from sea urchin (T. pileolus) inhibits 45Ca2+ uptake in P2 fraction from chick brain under physiological ionic conditions

Toxicon. 1999 Nov;37(11):1639-43. doi: 10.1016/s0041-0101(99)00094-x.

Abstract

An acidic toxic extract from the sea urchin T. pileolus inhibited time-dependent 45Ca2+ uptake in chick P2 fraction (IC50 about 10 ng/ml). This toxic extract is susceptible to trypsin. The inhibitory effect probably relate to Na+/Ca2+ exchanger.

MeSH terms

  • Animals
  • Brain Chemistry / drug effects*
  • Calcium / metabolism*
  • Calcium Radioisotopes
  • Chickens / metabolism*
  • Chromatography, Ion Exchange
  • Hydrolysis
  • In Vitro Techniques
  • Kinetics
  • Marine Toxins / chemistry
  • Marine Toxins / pharmacology*
  • Protein Denaturation
  • Sea Urchins / chemistry*
  • Tissue Extracts / chemistry
  • Tissue Extracts / pharmacology*
  • Trypsin

Substances

  • Calcium Radioisotopes
  • Marine Toxins
  • Tissue Extracts
  • Trypsin
  • Calcium