The joint impact of family history of myocardial infarction and other risk factors on 12-year coronary heart disease mortality

J M Boer; E J Feskens; W M Verschuren; J C Seidell; D Kromhout

The joint impact of family history of myocardial infarction and other risk factors on 12-year coronary heart disease mortality

Epidemiology. 1999 Nov;10(6):767-70.

Authors

J M Boer¹, E J Feskens, W M Verschuren, J C Seidell, D Kromhout

Affiliation

¹ Department of Chronic Disease Epidemiology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.

PMID: 10535794

Abstract

We investigated the impact of family history of myocardial infarction on 12-year coronary heart disease mortality. Men and women with a family history had an increased risk for coronary heart disease death, irrespective of other risk factors (RR = 1.58; 95% CI = 1.17-2.13 and RR = 2.12; 95% CI = 1.11-4.05, respectively). Women with a family history seemed to be more susceptible to the detrimental effects of smoking; not to the effects of other risk factors. We found no effect modification by family history in men.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Body Weight
Coronary Disease / mortality*
Female
Humans
Life Style
Male
Middle Aged
Myocardial Infarction / genetics*
Netherlands / epidemiology
Risk Factors
Smoking