Abstract
In sexual transmission of simian immunodeficiency virus, and early and later stages of human immunodeficiency virus-type 1 (HIV-1) infection, both viruses were found to replicate predominantly in CD4(+) T cells at the portal of entry and in lymphoid tissues. Infection was propagated not only in activated and proliferating T cells but also, surprisingly, in resting T cells. The infected proliferating cells correspond to the short-lived population that produces the bulk of HIV-1. Most of the HIV-1-infected resting T cells persisted after antiretroviral therapy. Latently and chronically infected cells that may be derived from this population pose challenges to eradicating infection and developing an effective vaccine.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-HIV Agents / therapeutic use
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology
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CD4-Positive T-Lymphocytes / virology*
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Cell Cycle
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Cervix Uteri / virology
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Epithelial Cells / virology
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Female
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HIV Infections / drug therapy
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HIV Infections / transmission*
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HIV Infections / virology
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HIV-1 / physiology*
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Lymph Nodes / virology
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Lymphocyte Activation*
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Macaca mulatta
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RNA, Viral / analysis
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Simian Acquired Immunodeficiency Syndrome / transmission*
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Simian Acquired Immunodeficiency Syndrome / virology
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Simian Immunodeficiency Virus / physiology*
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Time Factors
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Virus Replication
Substances
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Anti-HIV Agents
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RNA, Viral