Abstract
DsbA, a periplasmic thiol:disulphide oxidoreductase, catalyses the folding of various factors, among which are virulence determinants or the components of type III secretory machinery. It is also necessary for intracellular survival and cell-to-cell spread of the intracellular pathogen Shigella flexneri.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Bacterial Proteins / metabolism
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Bacterial Toxins / metabolism
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Biological Transport, Active
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Fimbriae, Bacterial / physiology
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Gram-Negative Bacteria / cytology
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Gram-Negative Bacteria / enzymology
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Gram-Negative Bacteria / metabolism
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Gram-Negative Bacteria / pathogenicity*
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HeLa Cells / microbiology
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HeLa Cells / ultrastructure
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Humans
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Microscopy, Electron
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Mutation
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Oxidation-Reduction
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Periplasm / enzymology
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Plants / microbiology
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Protein Disulfide-Isomerases / chemistry
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Protein Disulfide-Isomerases / genetics
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Protein Disulfide-Isomerases / physiology*
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Protein Folding
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Shigella flexneri / cytology
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Shigella flexneri / enzymology
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Shigella flexneri / metabolism
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Shigella flexneri / pathogenicity*
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Virulence
Substances
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Bacterial Proteins
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Bacterial Toxins
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Protein Disulfide-Isomerases