Multiple sclerosis is a highly complex disease due to the great diversity of symptoms and signs from disseminated demyelinating CNS lesions which lead to different levels of handicap, and to the different types of evolution (exacerbations or slow progression). Most of the patients with multiple sclerosis have a normal longevity. The main concern is the accumulation of disabilities. In order to follow accurately the progression of these disabilities, specific scales, especially EDSS, have been validated allowing more uniformity in method of collecting data from multiple sclerosis.