Abstract
FK506-related leukoencephalopathy has been reported to be reversible and readily treated by discontinuation or reduction of FK506. We describe two pediatric cases of FK506-related leukoencephalopathy following allogeneic bone marrow transplantation, which could not be readily controlled. These cases show that FK506-related leukoencephalopathy is not always reversible, and patients may develop epilepsy. Bone Marrow Transplantation (2000) 25, 331-334.
MeSH terms
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Acute Disease
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Adolescent
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Child, Preschool
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Cyclosporine / adverse effects
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Dementia, Vascular / chemically induced*
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Dementia, Vascular / pathology
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Electroencephalography
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Female
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Graft vs Host Disease / therapy
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Humans
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Immunosuppressive Agents / adverse effects*
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Immunosuppressive Agents / therapeutic use
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
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Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
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Leukemia, Myeloid / complications
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Leukemia, Myeloid / therapy
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Magnetic Resonance Imaging
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Male
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Seizures
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Tacrolimus / administration & dosage
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Tacrolimus / adverse effects*
Substances
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Immunosuppressive Agents
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Cyclosporine
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Tacrolimus