FK506-induced intractable leukoencephalopathy following allogeneic bone marrow transplantation

Bone Marrow Transplant. 2000 Feb;25(3):331-4. doi: 10.1038/sj.bmt.1702143.

Abstract

FK506-related leukoencephalopathy has been reported to be reversible and readily treated by discontinuation or reduction of FK506. We describe two pediatric cases of FK506-related leukoencephalopathy following allogeneic bone marrow transplantation, which could not be readily controlled. These cases show that FK506-related leukoencephalopathy is not always reversible, and patients may develop epilepsy. Bone Marrow Transplantation (2000) 25, 331-334.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adolescent
  • Child, Preschool
  • Cyclosporine / adverse effects
  • Dementia, Vascular / chemically induced*
  • Dementia, Vascular / pathology
  • Electroencephalography
  • Female
  • Graft vs Host Disease / therapy
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Leukemia, Myeloid / complications
  • Leukemia, Myeloid / therapy
  • Magnetic Resonance Imaging
  • Male
  • Seizures
  • Tacrolimus / administration & dosage
  • Tacrolimus / adverse effects*

Substances

  • Immunosuppressive Agents
  • Cyclosporine
  • Tacrolimus