Oculocardial reflex (OCR) occurs particularly through manipulation of the medial rectus muscle and results in a bradycardic arrhythmia. In children the incidence is between 60 and 80%. After using sevoflurane in clinical practice, the absence or non-occurrence of this reflex was observed. The data of 180 healthy children aged between four and 14 years who had to undergo strabismus surgery under general anaesthesia were analysed: group I (n = 92), group II (n = 88). All children received standard premedication with midazolam, no anticholinergic drugs were administered. During narcosis, analgesia was maintained routinely with alfentanil. In group I sevoflurane was inhaled for hypnosis and in group II propofol was injected as intravenous hypnotic drug. The depth of anaesthesia was adjusted according to clinical criteria. To compare both groups, heart rate (HR) was determined before, during and after surgical intervention. OCR was defined as a heart rate declining by more than 20% from the initial HR.OCR is described in all methods of general anaesthesia. Under sevoflurane the occurrence of the reflex was significantly (p < 0.05) reduced to 14% of all patients as compared to 75% in patients who received a propofol infusion. Sufficient reflex reduction according to the depth of narcosis under sevoflurane in combination with the sympathomimetic effects of this drug could therefore be discussed as a reason for its positive effects. In our opinion, the use of sevoflurane should be considered as an option for general anaesthesia in strabismus surgery.