Inverse relation between plasma G-CSF levels and neutrophil counts in a patient with autoimmune neutropenia treated with G-CSF

Clin Lab Haematol. 2000 Apr;22(2):119-20. doi: 10.1046/j.1365-2257.2000.00290.x.

Abstract

The pharmacokinetic characteristics of granulocyte colony-stimulating factor (G-CSF) appears to be related to the neutrophil count. We report the case of an 81-year-old male with acquired antibody induced neutropenia treated with G-CSF. This produced a rapid increase in the neutrophil count which appeared to be associated with diminished trough plasma G-CSF levels. Our data appears to indicate that mature neutrophils may play a part in the clearance of G-CSF from plasma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Autoimmune Diseases / drug therapy
  • Granulocyte Colony-Stimulating Factor / administration & dosage
  • Granulocyte Colony-Stimulating Factor / blood
  • Granulocyte Colony-Stimulating Factor / pharmacokinetics*
  • Humans
  • Isoantigens / blood
  • Male
  • Neutropenia / blood
  • Neutropenia / drug therapy*
  • Neutropenia / immunology
  • Neutrophils / cytology
  • Neutrophils / drug effects*
  • Receptors, IgG / blood
  • Time Factors

Substances

  • Isoantigens
  • Receptors, IgG
  • neutrophil-specific antigen SH
  • Granulocyte Colony-Stimulating Factor