Abstract
The pharmacokinetic characteristics of granulocyte colony-stimulating factor (G-CSF) appears to be related to the neutrophil count. We report the case of an 81-year-old male with acquired antibody induced neutropenia treated with G-CSF. This produced a rapid increase in the neutrophil count which appeared to be associated with diminished trough plasma G-CSF levels. Our data appears to indicate that mature neutrophils may play a part in the clearance of G-CSF from plasma.
MeSH terms
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Aged
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Aged, 80 and over
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Autoimmune Diseases / drug therapy
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Granulocyte Colony-Stimulating Factor / administration & dosage
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Granulocyte Colony-Stimulating Factor / blood
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Granulocyte Colony-Stimulating Factor / pharmacokinetics*
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Humans
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Isoantigens / blood
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Male
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Neutropenia / blood
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Neutropenia / drug therapy*
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Neutropenia / immunology
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Neutrophils / cytology
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Neutrophils / drug effects*
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Receptors, IgG / blood
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Time Factors
Substances
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Isoantigens
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Receptors, IgG
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neutrophil-specific antigen SH
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Granulocyte Colony-Stimulating Factor