Therapeutic approaches to Alzheimer's disease

Curr Opin Chem Biol. 2000 Aug;4(4):377-82. doi: 10.1016/s1367-5931(00)00102-2.

Abstract

Several recent advances have provided new insights and possibilities in defining therapeutic targets for Alzheimer's disease. Of particular importance is the identification of the beta-secretase enzyme and the demonstration that immunization of a transgenic mouse model of Alzheimer's disease with Abeta(1-42) peptide can prevent or alleviate neuropathological features of the disease.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / enzymology
  • Alzheimer Disease / therapy*
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / immunology
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Aspartic Acid Endopeptidases / metabolism
  • Disease Models, Animal
  • Endopeptidases
  • Humans
  • Immunization
  • Mice
  • Mice, Transgenic
  • Molecular Structure
  • Peptide Fragments / immunology
  • Plaque, Amyloid / metabolism

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Peptide Fragments
  • amyloid beta-protein (1-42)
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE2 protein, human
  • BACE1 protein, human
  • Bace1 protein, mouse