Abstract
Perception of external stimuli is often mediated through the activity of a G protein-coupled receptor in response to its ligand. Receptor-mediated internalization allows the insertion of toxins that cause the elimination of receptor-expressing neurons. Using this technique new information on systems biology can be discovered and with this, new therapeutics developed.
Copyright 2000 Harcourt Publishers Ltd.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacokinetics*
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Endocytosis / physiology
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GTP-Binding Proteins / metabolism*
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Immunotoxins*
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N-Glycosyl Hydrolases*
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Plant Proteins / pharmacokinetics*
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Receptors, Neurokinin-1 / metabolism*
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Ribosome Inactivating Proteins, Type 1
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Saporins
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Signal Transduction / physiology
Substances
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Antineoplastic Agents, Phytogenic
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Immunotoxins
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Plant Proteins
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Receptors, Neurokinin-1
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Ribosome Inactivating Proteins, Type 1
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N-Glycosyl Hydrolases
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Saporins
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GTP-Binding Proteins