Restoration of immunity with interleukin-2 therapy

K A Smith; E L Jacobson; R Emert; M Giordano; E Kovacs; N Mumneh; F Pilaro; T Sohn; D Warren

Restoration of immunity with interleukin-2 therapy

AIDS Read. 1999 Nov;9(8):563-72.

Authors

K A Smith¹, E L Jacobson, R Emert, M Giordano, E Kovacs, N Mumneh, F Pilaro, T Sohn, D Warren

Affiliation

¹ Department of Medicine, Weill Medical College of Cornell University, New York, USA.

PMID: 11082734

Abstract

HIV replication can now be effectively suppressed using antiretroviral combination regimens. The search continues, however, for ways to restore the immune response and eliminate reservoirs of latent infection. Interleukin-2 (IL-2) may augment the immune response in HIV-infected persons. This article discusses the rationale for using IL-2 in those with HIV disease and reviews key trials of IL-2 treatment regimens.

Publication types

Review

MeSH terms

Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Dose-Response Relationship, Drug
HIV Infections / drug therapy
HIV Infections / immunology*
Humans
Immune System / drug effects*
Immunity / drug effects
Immunotherapy
Interleukin-2 / administration & dosage
Interleukin-2 / pharmacology
Interleukin-2 / therapeutic use*
Killer Cells, Natural / drug effects
Killer Cells, Natural / immunology
Receptors, Interleukin-2 / drug effects
Receptors, Interleukin-2 / immunology
Virus Latency / drug effects
Virus Latency / immunology

Substances

Interleukin-2
Receptors, Interleukin-2