Isolation of a potent anti-MRSA sesquiterpenoid quinone from Ulmus davidiana var. japonica

Chem Pharm Bull (Tokyo). 2000 Nov;48(11):1805-6. doi: 10.1248/cpb.48.1805.

Abstract

A highly potent anti-MRSA sesquiterpenoid has been isolated from Ulmus davidiana var. japonica, which has been traditionally used to treat infectious diseases in Korea. This naturally occurring antibiotic was identified as mansonone F (1). This compound has been found to be highly active specifically against MRSA and showed an MIC range of 0.39-3.13 microg/ml which is comparable to that of vancomycin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Bacteria / drug effects
  • Korea
  • Methicillin Resistance*
  • Microbial Sensitivity Tests
  • Plant Epidermis / chemistry
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Quinones / isolation & purification
  • Quinones / pharmacology*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology*
  • Staphylococcus aureus / drug effects*

Substances

  • Anti-Bacterial Agents
  • Quinones
  • Sesquiterpenes