The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function

Immunol Today. 2000 Dec;21(12):611-4. doi: 10.1016/s0167-5699(00)01745-x.

Abstract

DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Alzheimer Disease / enzymology
  • Alzheimer Disease / genetics
  • Amino Acid Motifs
  • Animals
  • Bone Cysts / enzymology
  • Bone Cysts / genetics
  • Enzyme Precursors / physiology
  • Hematopoiesis / physiology
  • Humans
  • Immunologic Deficiency Syndromes / genetics
  • Immunologic Deficiency Syndromes / metabolism
  • Intracellular Signaling Peptides and Proteins
  • Killer Cells, Natural / metabolism*
  • Killer Cells, Natural / physiology
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Models, Animal
  • Myeloid Cells / metabolism*
  • Myeloid Cells / physiology
  • Organ Specificity
  • Protein-Tyrosine Kinases / physiology
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / physiology
  • Receptors, Immunologic / chemistry
  • Receptors, Immunologic / deficiency
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / physiology*
  • Signal Transduction
  • Species Specificity
  • Syk Kinase
  • ZAP-70 Protein-Tyrosine Kinase

Substances

  • Adaptor Proteins, Signal Transducing
  • Enzyme Precursors
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Immunologic
  • TYROBP protein, human
  • Protein-Tyrosine Kinases
  • SYK protein, human
  • Syk Kinase
  • Syk protein, mouse
  • ZAP-70 Protein-Tyrosine Kinase
  • ZAP70 protein, human
  • Zap70 protein, mouse