[Primary lateral sclerosis with breast cancer, a potential paraneoplastic neurological syndrome]

Rev Neurol (Paris). 2000 Nov;156(11):1020-2.
[Article in French]

Abstract

Few reports indicate that motor neuron diseases may have paraneoplastic origin. A 70 year-old woman suffering from progressive upper motor neuron disease is presented. Laboratory, radiological and neurophysiologic studies were compatible with primary lateral sclerosis. Six years later a routine screening led to the discovery of a breast cancer, suggesting that the upper motor neuron syndrome could be paraneoplastic. So, in female patients with primary lateral sclerosis, a mammography should be recommended to search for breast cancer.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use
  • Brain / pathology
  • Breast Neoplasms / complications*
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / therapy
  • Combined Modality Therapy
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Motor Neuron Disease / diagnosis*
  • Motor Neuron Disease / etiology*
  • Paraneoplastic Syndromes, Nervous System / diagnosis*
  • Paraneoplastic Syndromes, Nervous System / etiology*
  • Tamoxifen / therapeutic use

Substances

  • Antineoplastic Agents
  • Tamoxifen