Delivery systems for parenteral nutrition have to be based on fundamental principles regarding venous access, choice of intravenous line, need for inline filters, infusion rate control and mode of packaging into "all in one" bags/two line/or the older three line system and, above all, the aseptic maintenance of this delivery system. Delivery systems need to be modified as per the available resources and hospital where they are to be used. Central venous access and handling of lines demand a high level of dedication and discipline, ideally left to a dedicated team of nurses and doctors. Staff training is the key factor in developing an efficient delivery system.