Idiopathic thrombocytopenic purpura and MMR vaccine

E Miller; P Waight; C P Farrington; N Andrews; J Stowe; B Taylor

doi:10.1136/adc.84.3.227

Idiopathic thrombocytopenic purpura and MMR vaccine

Arch Dis Child. 2001 Mar;84(3):227-9. doi: 10.1136/adc.84.3.227.

Authors

E Miller¹, P Waight, C P Farrington, N Andrews, J Stowe, B Taylor

Affiliation

¹ Immunisation Division, Public Health Laboratory Service Communicable Disease Surveillance Centre, Colindale, London NW9 5EQ, UK. e.miller@phls.co.uk

Abstract

A CAUSAL ASSOCIATION BETWEEN MEASLES: mumps-rubella (MMR) vaccine and idiopathic thrombocytopenic purpura (ITP) was confirmed using immunisation/hospital admission record linkage. The absolute risk within six weeks of immunisation was 1 in 22 300 doses, with two of every three cases occurring in the six week post-immunisation period being caused by MMR. Children with ITP before MMR had no vaccine associated recurrences.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Humans
Incidence
Infant
Male
Measles-Mumps-Rubella Vaccine / adverse effects*
Medical Record Linkage
Purpura, Thrombocytopenic, Idiopathic / epidemiology
Purpura, Thrombocytopenic, Idiopathic / etiology*
Risk Factors
United Kingdom / epidemiology

Substances

Measles-Mumps-Rubella Vaccine