[Primary Neisseria meningitidis arthritis of the knee without meningitis: contribution of synovial fluid culture in blood-culture vial]

Rev Med Interne. 2001 Jan;22(1):75-8. doi: 10.1016/s0248-8663(00)00289-7.
[Article in French]

Abstract

Introduction: Primary meningococcal arthritis is a rare form of meningococcal disease. It occurs as an isolated acute purulent arthritis without meningitis, and presence of Neisseria meningitidis in articular fluid. We report a new case of typical primary meningococcal arthritis.

Exegesis: A previously healthy 23-year-old female patient was admitted for purpuric lesions of the legs. At admission, conscience was normal and symptoms of meningitis were absent. During the 2nd day of hospitalisation, a warm and painful effusion in the right knee appeared. Aspiration from the right knee yielded a purulent fluid. N. meningitidis was isolated from a blood-culture vial inoculated with the synovial fluid, while blood cultures remained sterile. Anti-biotherapy was initiated as soon as microbiological diagnosis was established. The patient was symptom-free 1 month later.

Conclusion: We emphasize the fact that agar cultures of the synovial fluid remained sterile, while N. meningitidis grew in a blood-culture vial. We suggest that diagnosis of primary meningococcal arthritis may be underestimated when inappropriate culture media are used.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arthritis, Infectious / diagnosis
  • Arthritis, Infectious / pathology*
  • Blood Specimen Collection
  • Colony Count, Microbial
  • Female
  • Humans
  • Knee Joint / microbiology*
  • Meningococcal Infections / diagnosis
  • Meningococcal Infections / pathology*
  • Neisseria meningitidis / isolation & purification*
  • Synovial Fluid / microbiology