Blockade of the CD28/B7 and CD40/CD40L costimulatory pathways does not ameliorate chronic rejection in a mouse aortic allograft model of direct antigen presentation

Transplant Proc. 2001 Feb-Mar;33(1-2):382. doi: 10.1016/s0041-1345(00)02058-3.

Authors

J L Tang¹, J E Woodward, V Subbotin, A J Logar, H Sun, L A Valdivia, A T Schaefer, L B Zottola, R Peach, J J Fung, A S Rao

Affiliation

¹ Section of Cellular Transplantation, Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

PMID: 11266872
DOI: 10.1016/s0041-1345(00)02058-3

No abstract available

MeSH terms

Animals
Antigen Presentation
Aorta / pathology
Aorta / transplantation*
B7-1 Antigen / immunology
CD28 Antigens / immunology*
CD40 Antigens / immunology*
CD40 Ligand / immunology
Chronic Disease
Graft Rejection / immunology
Graft Rejection / pathology
Graft Rejection / prevention & control*
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Signal Transduction
Transplantation, Homologous
Tunica Intima / pathology

Substances

B7-1 Antigen
CD28 Antigens
CD40 Antigens
CD40 Ligand