Gene therapy of malignant gliomas: a pilot study of vaccination with irradiated autologous glioma and dendritic cells admixed with IL-4 transduced fibroblasts to elicit an immune response

Hum Gene Ther. 2001 Mar 20;12(5):575-95. doi: 10.1089/104303401300042528.
No abstract available

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Animals
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / immunology
  • Brain Neoplasms / radiotherapy
  • Brain Neoplasms / therapy*
  • Cancer Vaccines / genetics*
  • Cell Division
  • Cells, Cultured
  • Cytokines / biosynthesis
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fibroblasts / immunology
  • Fibroblasts / metabolism*
  • Flow Cytometry
  • Glioma / genetics*
  • Glioma / immunology
  • Glioma / radiotherapy
  • Glioma / therapy*
  • Humans
  • Immunohistochemistry
  • Interleukin-4 / genetics*
  • Leukapheresis
  • Male
  • Middle Aged
  • Phenotype
  • Pilot Projects
  • Rats
  • Retroviridae / genetics
  • T-Lymphocytes, Cytotoxic / metabolism
  • Transduction, Genetic*
  • Treatment Outcome

Substances

  • Cancer Vaccines
  • Cytokines
  • Interleukin-4