Abstract
PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The constitutive expression of PD-1 ligands (PD-L1 and PD-L2) on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD
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Antigens, Surface / metabolism*
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Apoptosis Regulatory Proteins
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Autoimmune Diseases / etiology*
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Autoimmune Diseases / immunology
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B7-1 Antigen
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CD28 Antigens
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Cardiomyopathy, Dilated / etiology
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Cardiomyopathy, Dilated / immunology
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Humans
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Immune Tolerance*
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Ligands
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Mice
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Models, Immunological
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Programmed Cell Death 1 Receptor
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Receptors, Immunologic / metabolism*
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Signal Transduction
Substances
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Antigens, CD
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Antigens, Surface
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Apoptosis Regulatory Proteins
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B7-1 Antigen
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CD28 Antigens
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Ligands
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PDCD1 protein, human
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Pdcd1 protein, mouse
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Programmed Cell Death 1 Receptor
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Receptors, Immunologic