Evolution of functionality in lattice proteins

J Mol Graph Model. 2001;19(1):150-6. doi: 10.1016/s1093-3263(00)00125-x.

Abstract

We study the evolution of protein functionality using a two-dimensional lattice model. The characteristics particular to evolution, such as population dynamics and early evolutionary trajectories, have a large effect on the distribution of observed structures. Only subtle differences are observed between the distribution of structures evolved for function and those evolved for their ability to form compact structures.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Evolution, Molecular*
  • Ligands
  • Mathematics
  • Protein Binding
  • Protein Conformation*
  • Proteins / chemistry*
  • Proteins / metabolism
  • Statistics as Topic
  • Time Factors

Substances

  • Ligands
  • Proteins