MEK inhibitor augments IL-6-induced growth arrest and apoptosis, but antagonizes IL-6-induced macrophage differentiation of M1 cells

Immunol Lett. 2001 Jul 2;77(3):165-7. doi: 10.1016/s0165-2478(01)00207-3.
No abstract available

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Cell Adhesion / drug effects
  • Cell Differentiation / drug effects
  • Cell Division / drug effects
  • DNA-Binding Proteins / metabolism
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors / pharmacology
  • Flavonoids / pharmacology*
  • Interleukin-6 / pharmacology*
  • MAP Kinase Signaling System / drug effects
  • Macrophage-1 Antigen / metabolism
  • Macrophages / cytology
  • Macrophages / drug effects*
  • Macrophages / physiology*
  • Mice
  • Mitogen-Activated Protein Kinases / antagonists & inhibitors*
  • Mitogen-Activated Protein Kinases / metabolism
  • Phagocytosis / drug effects
  • STAT3 Transcription Factor
  • Trans-Activators / metabolism
  • Tumor Cells, Cultured

Substances

  • DNA-Binding Proteins
  • Enzyme Inhibitors
  • Flavonoids
  • Interleukin-6
  • Macrophage-1 Antigen
  • STAT3 Transcription Factor
  • Stat3 protein, mouse
  • Trans-Activators
  • Mitogen-Activated Protein Kinases
  • 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one