Outcomes for cancer patients undergoing mechanical ventilation have improved in recent times, and the outlook for this patient group is no longer hopeless. Advances in ventilation techniques and increasingly sophisticated equipment have allowed oncologic intensivists to intervene more effectively in their patients' critical illness. In addition, many of these patients are now referred for intensive care much earlier. This article reviews the use of mechanical ventilation in critically ill cancer patients and includes discussion of the recently published outcome literature. We also discuss some recent advances in the broader field of mechanical ventilation and demonstrate how these advances can be applied to the oncology population.