Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice

F N Lauw; S Florquin; P Speelman; S J van Deventer; T van der Poll

doi:10.1128/IAI.69.9.5949-5952.2001

Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice

Infect Immun. 2001 Sep;69(9):5949-52. doi: 10.1128/IAI.69.9.5949-5952.2001.

Authors

F N Lauw¹, S Florquin, P Speelman, S J van Deventer, T van der Poll

Affiliation

¹ Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands.

Abstract

In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.

MeSH terms

Animals
Enterotoxins / administration & dosage*
Enterotoxins / immunology*
Interleukin-12 / metabolism*
Interleukin-18 / metabolism
Mice
Spleen / immunology
Staphylococcus aureus / metabolism*
Superantigens / administration & dosage
Superantigens / immunology

Substances

Enterotoxins
Interleukin-18
Superantigens
Interleukin-12
enterotoxin B, staphylococcal