In order to study the effect of microgravity on mammalian cell growth, proliferation and biosynthesis, the human T leukemia cells, human lung adenocarcinoma cells, EVI-H1 hybridoma cells and genetic engineering cells producing human growth hormone were flown on re-entry Scientific Satellite 90105 for a duration of eight days. The preliminary results indicate that the mammalian cells are sensitive to gravity. They might adapt to microgravity conditions leading to altered growth rate and subsequently, to altered biosynthesis and molecular secretion. In addition, their morphology may be affected in microgravity.