The deleterious effect of low-quality housing and related environmental factors on the physical and mental health of its residents is a widely accepted phenomenon. Yet low-quality housing continues to exist, partly because of the nature of housing as a commodity in a capitalist system. This paper defines three political-analytic perspectives within which the housing-health relationship can be seen: individualistic, reformist, and dialectical-materialist. These approaches incorporate perspectives on the nature of the relationship as well as strategic implications arising from them. In this context, the housing-health relationship is examined in fact and interpretation from the 1840s to the present. All three perspectives are illustrated by various popular analyses of changes in urban form and housing as well as the housing-health relationship. The dependence of housing quality on the mode of production is shown, demonstrating the weaknesses of the individualistic and reformist perspectives, which assume housing quality to be independent of the mode of production. The different strategic implications of the three perspectives are illustrated in the conclusion in a discussion of the case of lead paint poisoning.