The main discoveries performed by scientists working the Rhône-Poulenc groups are listed, from 1895, date of the creation of Société chimique des usines du Rhône, to 1996. Analgesics, hypnotics, drugs useful for surgery, Tropical diseases, antihistaminics, neuroleptics, antibacterial agents, drugs acting in the cardio-vascular system, anti-cancer agents and drugs discovered by companies who joined the groups are briefly presented. Biotechnologies are also evoked.