Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics

M Granzow; S Popp; S Weber; B Schoell; H Holtgreve-Grez; L Senf; D Hager; J Boschert; W Scheurlen; A Jauch

doi:10.1016/s0165-4608(01)00465-4

Isochromosome 1q as an early genetic event in a child with intracranial ependymoma characterized by molecular cytogenetics

Cancer Genet Cytogenet. 2001 Oct 1;130(1):79-83. doi: 10.1016/s0165-4608(01)00465-4.

Authors

M Granzow¹, S Popp, S Weber, B Schoell, H Holtgreve-Grez, L Senf, D Hager, J Boschert, W Scheurlen, A Jauch

Affiliation

¹ Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, D-69120, Heidelberg, Germany.

PMID: 11672779
DOI: 10.1016/s0165-4608(01)00465-4

Abstract

Data concerning cytogenetic features of childhood ependymoma are rare. In this article, a gain of 1q was identified as the sole alteration in a primary childhood infratentorial ependymoma by comparative genomic hybridization (CGH). A recurrence of this brain tumor was studied using multiplex-fluorescence in situ hybridization (M-FISH) in addition to CGH and G-banding analysis. In accordance with the primary tumor, a gain of 1q corresponding to an isochromosome 1q was observed indicating an early event in the tumor development. Furthermore, M-FISH classified several other rearranged chromosomes including 6q and 17p that have previously been found to be involved in the development and progression of childhood ependymoma.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Brain Neoplasms / genetics*
Child, Preschool
Chromosome Aberrations*
Chromosomes, Human, Pair 1*
Ependymoma / genetics*
Humans
In Situ Hybridization, Fluorescence
Male