Abstract
We report a patient with cyclic thrombocytopenia and antiplatelet antibodies, a variant of chronic immune thrombocytopenic purpura (ITP), with a several year history of periodic fluctuation of the platelet count, megakaryocytic hyperplasia and high-titer anti-GPIb-specific antiplatelet antibodies. The patient was resistant to multiple forms of therapy but has responded to the thrombopoietic growth factor, pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF). This case suggests that some patients with classic ITP may respond to thrombopoietic growth factors.
Copyright 2001 Wiley-Liss, Inc.
MeSH terms
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Aged
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Autoantibodies / blood
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Female
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Humans
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Platelet Count
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Platelet Glycoprotein GPIb-IX Complex / immunology
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Polyethylene Glycols / administration & dosage*
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Polyethylene Glycols / therapeutic use*
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Purpura, Thrombocytopenic, Idiopathic / drug therapy*
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Purpura, Thrombocytopenic, Idiopathic / etiology
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Purpura, Thrombocytopenic, Idiopathic / immunology
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Recombinant Proteins / administration & dosage*
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Recombinant Proteins / therapeutic use*
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Thrombocytopenia / drug therapy*
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Thrombocytopenia / etiology
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Thrombocytopenia / immunology
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Thrombopoietin / administration & dosage*
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Thrombopoietin / blood
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Thrombopoietin / deficiency
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Thrombopoietin / therapeutic use*
Substances
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Autoantibodies
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Platelet Glycoprotein GPIb-IX Complex
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Recombinant Proteins
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polyethylene glycol-recombinant human megakaryocyte growth and development factor
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Polyethylene Glycols
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Thrombopoietin