Resuppression of virus load after interruption in treatment with nevirapine and 2 nucleoside reverse-transcriptase inhibitors

Clin Infect Dis. 2002 Feb 15;34(4):547-50. doi: 10.1086/338726. Epub 2002 Jan 11.

Abstract

This retrospective chart review evaluated the effectiveness of reinitiation of treatment with nevirapine and dual nucleoside-analogue reverse-transcriptase inhibitors (NRTIs) after an interruption in antiretroviral therapy in 135 patients with human immunodeficiency virus type 1 RNA levels of <400 copies/mL who were receiving the same regimen. Reinitiation of a nevirapine regimen resulted in resuppression of virus load to <400 copies/mL in most patients who adhered to the regimen. Direct interruption of a non-NRTI regimen could lead to easier and more efficient structured protocols for treatment interruption.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiretroviral Therapy, Highly Active
  • HIV Infections / drug therapy*
  • HIV-1 / drug effects*
  • HIV-1 / physiology
  • Humans
  • Nevirapine / therapeutic use*
  • RNA, Viral / analysis
  • Retrospective Studies
  • Reverse Transcriptase Inhibitors / therapeutic use*
  • Treatment Outcome
  • Viral Load

Substances

  • RNA, Viral
  • Reverse Transcriptase Inhibitors
  • Nevirapine