Objectives: To explore the susceptibility to esophageal carcinoma (EC) in different population with different cytochrome P450 IA1 (CYPIA1) genotype, and study the synergistic effects between CYPIA1 and smoking.
Methods: A case-control study (case = 111, control = 114) was used to compare the frequency of CYPIA1 genotype between EC and controls with a PCR method.
Results: The distribution of three genotypes of CYPIA1 in EC and controls was significantly different (chi(2) = 19.35, P < 0.01). There was a synergistic effect between the mutation of CYPIA1 4,889 site and smoking (SIA = 1.56), and a significant dose-response effect was observed. The risk of individual whose CYPIA1 4,889 site is mutated was 3 times higher than those not mutated.
Conclusions: The mutation of CYPIA1 ,89 site maybe one of important host susceptible factors of EC, and the risk would increase significantly in smokers.