Combinatorial approaches to inhibitors of VLA-4: piperazine-peptoid-bisarylureas

Mol Divers. 2000;5(2):61-73. doi: 10.1023/a:1013990624215.

Abstract

A combinatorial approach towards identifying inhibitors of VALA-4 was investigated. A library of piperazine-peptoid-bisarylureas was assembled in solid phase and screening in the novel v-well assay enabled the identification of active compounds.

MeSH terms

  • Chromatography, High Pressure Liquid
  • Combinatorial Chemistry Techniques*
  • Databases as Topic
  • Dimethyl Sulfoxide / chemistry
  • Dimethylformamide / chemistry
  • Integrin alpha4beta1
  • Integrins / antagonists & inhibitors*
  • Integrins / chemistry*
  • Mass Spectrometry
  • Models, Chemical
  • Peptide Library
  • Peptides / chemical synthesis
  • Peptides / chemistry*
  • Peptoids
  • Piperazine
  • Piperazines / pharmacology*
  • Receptors, Lymphocyte Homing / antagonists & inhibitors*
  • Receptors, Lymphocyte Homing / chemistry*
  • Software
  • Triazoles / chemistry

Substances

  • Integrin alpha4beta1
  • Integrins
  • Peptide Library
  • Peptides
  • Peptoids
  • Piperazines
  • Receptors, Lymphocyte Homing
  • Triazoles
  • Piperazine
  • Dimethylformamide
  • 1-hydroxybenzotriazole
  • Dimethyl Sulfoxide