Abstract
A combinatorial approach towards identifying inhibitors of VALA-4 was investigated. A library of piperazine-peptoid-bisarylureas was assembled in solid phase and screening in the novel v-well assay enabled the identification of active compounds.
MeSH terms
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Chromatography, High Pressure Liquid
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Combinatorial Chemistry Techniques*
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Databases as Topic
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Dimethyl Sulfoxide / chemistry
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Dimethylformamide / chemistry
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Integrin alpha4beta1
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Integrins / antagonists & inhibitors*
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Integrins / chemistry*
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Mass Spectrometry
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Models, Chemical
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Peptide Library
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Peptides / chemical synthesis
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Peptides / chemistry*
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Peptoids
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Piperazine
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Piperazines / pharmacology*
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Receptors, Lymphocyte Homing / antagonists & inhibitors*
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Receptors, Lymphocyte Homing / chemistry*
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Software
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Triazoles / chemistry
Substances
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Integrin alpha4beta1
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Integrins
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Peptide Library
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Peptides
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Peptoids
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Piperazines
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Receptors, Lymphocyte Homing
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Triazoles
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Piperazine
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Dimethylformamide
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1-hydroxybenzotriazole
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Dimethyl Sulfoxide