Abstract
Tumour-associated viruses produce antigens that, on the face of it, are ideal targets for immunotherapy. Unfortunately, these viruses are experts at avoiding or subverting the host immune response. Cervical-cancer-associated human papillomavirus (HPV) has a battery of immune-evasion mechanisms at its disposal that could confound attempts at HPV-directed immunotherapy. Other virally associated human cancers might prove similarly refractive to immuno-intervention unless we learn how to circumvent their strategies for immune evasion.
MeSH terms
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Animals
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Antigen Presentation
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Antigen-Presenting Cells / immunology
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Antigens, Viral / immunology
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Capsid / immunology
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Cell Transformation, Viral
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Codon / genetics
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Dendritic Cells / immunology
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Female
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Gene Expression Regulation, Viral
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Genetic Code
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Humans
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Immune Tolerance
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Immunologic Surveillance
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Interferons / physiology
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Keratinocytes / virology
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Mice
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Mice, Transgenic
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Molecular Mimicry
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Oncogene Proteins, Viral / immunology
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Oncogene Proteins, Viral / physiology
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Papillomaviridae / genetics
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Papillomaviridae / immunology*
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Papillomavirus Infections / immunology*
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Uterine Cervical Neoplasms / immunology*
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Uterine Cervical Neoplasms / virology
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Viral Proteins / genetics
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Viral Proteins / immunology
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Viral Proteins / physiology
Substances
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Antigens, Viral
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Codon
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Oncogene Proteins, Viral
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Viral Proteins
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Interferons