Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

J Virol. 2002 Apr;76(8):4108-12. doi: 10.1128/jvi.76.8.4108-4112.2002.

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Vaccines / administration & dosage
  • AIDS Vaccines / immunology*
  • Animals
  • HIV Infections / prevention & control
  • HIV-1 / immunology
  • Humans
  • Macaca
  • Simian Acquired Immunodeficiency Syndrome / prevention & control*
  • Simian Acquired Immunodeficiency Syndrome / virology*
  • Simian Immunodeficiency Virus / immunology
  • Simian Immunodeficiency Virus / physiology*
  • T-Lymphocytes, Cytotoxic / immunology
  • Vaccination
  • Vaccines, DNA / administration & dosage
  • Vaccines, DNA / immunology
  • Vaccinia virus / genetics
  • Viral Load
  • Virus Replication*

Substances

  • AIDS Vaccines
  • Vaccines, DNA
  • human immunodeficiency virus type 1 Tat vaccine