Abstract
The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right-handed superhelix of eight helices with charged surface patches probably serving as sites of protein-protein recognition and docking.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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Endosomal Sorting Complexes Required for Transport
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Molecular Sequence Data
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Phosphoproteins / chemistry
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Phosphoproteins / metabolism
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Protein Conformation
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Proteins / chemistry*
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Proteins / metabolism
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Sequence Alignment
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Sequence Homology, Amino Acid
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Signal Transduction
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trans-Golgi Network / metabolism
Substances
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Endosomal Sorting Complexes Required for Transport
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Phosphoproteins
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Proteins
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hepatocyte growth factor-regulated tyrosine kinase substrate