Emergence of multiple drug-resistant human cytomegalovirus variants in 2 patients with human immunodeficiency virus infection unresponsive to highly active antiretroviral therapy

Fausto Baldanti; Stefania Paolucci; Aldo Parisi; Luca Meroni; Giuseppe Gerna

doi:10.1086/339750

Emergence of multiple drug-resistant human cytomegalovirus variants in 2 patients with human immunodeficiency virus infection unresponsive to highly active antiretroviral therapy

Clin Infect Dis. 2002 Apr 15;34(8):1146-9. doi: 10.1086/339750. Epub 2002 Mar 19.

Authors

Fausto Baldanti¹, Stefania Paolucci, Aldo Parisi, Luca Meroni, Giuseppe Gerna

Affiliation

¹ Servizio di Virologia, and Laboratori Sperimentali di Ricerca, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Italy.

PMID: 11915006
DOI: 10.1086/339750

Abstract

In 2 patients infected with human immunodeficiency virus (HIV), highly active antiretroviral therapy was unable to suppress HIV replication as a result of the emergence of drug-resistant HIV variants. Human cytomegalovirus (HCMV) retinitis developed in both patients, and an unusually complex mixture of drug-resistant HCMV variants was detected in both patients.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

AIDS-Related Opportunistic Infections / virology*
Adult
Antiretroviral Therapy, Highly Active
Cytomegalovirus / drug effects*
Cytomegalovirus / isolation & purification
Cytomegalovirus Infections / etiology
Cytomegalovirus Infections / virology
Cytomegalovirus Retinitis / etiology
Cytomegalovirus Retinitis / virology*
Drug Resistance, Multiple*
HIV / drug effects
HIV Infections / complications*
HIV Infections / drug therapy
Humans
Male
Virus Replication / drug effects