[CD8-positive, CD30-negative cutaneous T-cell lymphoma simulating pyoderma gangrenosum]

Hautarzt. 2002 Feb;53(2):114-7. doi: 10.1007/s001050100232.
[Article in German]

Abstract

Ulcerated primary cutaneous lymphomas are not rare, but the clinical manifestation as a pyoderma gangrenosum look-alike is extraordinary. CD8-positive lymphomas are rare, unclassifiable tumours with variable prognosis. We report on a 49-year-old patient with a large ulcerated primary cutaneous lymphoma on the left chest wall presenting as pyoderma gangrenosum. With immunohistochemical staining, most lymphocytes were shown to be CD8-positive. The CD30 antigen was not expressed. After radiotherapy with complete skin irradiation, the lymphoma regressed completely. The patient has been free of relapse for 28 months so far.

Publication types

  • Case Reports

MeSH terms

  • CD8 Antigens / analysis*
  • Diagnosis, Differential
  • Humans
  • Ki-1 Antigen / analysis*
  • Lymphocytes / pathology
  • Lymphoma, T-Cell, Cutaneous / diagnosis*
  • Lymphoma, T-Cell, Cutaneous / pathology
  • Lymphoma, T-Cell, Cutaneous / radiotherapy
  • Male
  • Middle Aged
  • Pyoderma Gangrenosum / diagnosis*
  • Pyoderma Gangrenosum / pathology
  • Skin / pathology
  • Skin Neoplasms / diagnosis*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / radiotherapy

Substances

  • CD8 Antigens
  • Ki-1 Antigen