Pyloric gland-type tubular adenoma superimposed on intraductal papillary mucinous tumor of the pancreas. Pyloric gland adenoma of the pancreas

Virchows Arch. 2002 Feb;440(2):205-208. doi: 10.1007/s004280100535.

Abstract

We report a rare case of pyloric gland-type tubular adenoma of the main pancreatic duct. It was a grossly visible polypoid nodule and was composed of closely packed pyloric-type glands. This adenoma was present within an intraductal papillary mucinous adenoma (IPMA). In this IPMA lesion, aggregations of pyloric-type glands were occasionally observed, and most of the cells including ductal lining cells expressed pyloric gland-type mucin. The IPMA of the present case showed more extensive pyloric gland metaplasia or differentiation than commonly noted in IPMAs. We consider this pyloric gland-type tubular adenoma to be derived from a selective growth of IPMA cells showing pyloric gland metaplasia.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / complications
  • Adenoma / metabolism
  • Adenoma / pathology*
  • Aged
  • Antibodies, Monoclonal
  • Concanavalin A / analysis
  • DNA, Neoplasm / analysis
  • Exocrine Glands / metabolism
  • Exocrine Glands / pathology
  • Gallstones / etiology
  • Gallstones / pathology
  • Gallstones / surgery
  • Gastric Mucosa / metabolism
  • Gastric Mucosa / pathology*
  • Genes, ras
  • Humans
  • Immunohistochemistry
  • Male
  • Metaplasia
  • Mucins / analysis
  • Mucins / immunology
  • Mucins / metabolism
  • Mutation
  • Neoplasms, Second Primary / metabolism
  • Neoplasms, Second Primary / pathology*
  • Pancreatic Ducts / metabolism
  • Pancreatic Ducts / pathology*
  • Pancreatic Neoplasms / complications
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology*
  • Polymerase Chain Reaction

Substances

  • Antibodies, Monoclonal
  • DNA, Neoplasm
  • Mucins
  • Concanavalin A