Abstract
We report a rare case of pyloric gland-type tubular adenoma of the main pancreatic duct. It was a grossly visible polypoid nodule and was composed of closely packed pyloric-type glands. This adenoma was present within an intraductal papillary mucinous adenoma (IPMA). In this IPMA lesion, aggregations of pyloric-type glands were occasionally observed, and most of the cells including ductal lining cells expressed pyloric gland-type mucin. The IPMA of the present case showed more extensive pyloric gland metaplasia or differentiation than commonly noted in IPMAs. We consider this pyloric gland-type tubular adenoma to be derived from a selective growth of IPMA cells showing pyloric gland metaplasia.
MeSH terms
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Adenoma / complications
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Adenoma / metabolism
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Adenoma / pathology*
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Aged
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Antibodies, Monoclonal
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Concanavalin A / analysis
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DNA, Neoplasm / analysis
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Exocrine Glands / metabolism
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Exocrine Glands / pathology
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Gallstones / etiology
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Gallstones / pathology
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Gallstones / surgery
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Gastric Mucosa / metabolism
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Gastric Mucosa / pathology*
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Genes, ras
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Humans
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Immunohistochemistry
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Male
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Metaplasia
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Mucins / analysis
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Mucins / immunology
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Mucins / metabolism
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Mutation
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Neoplasms, Second Primary / metabolism
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Neoplasms, Second Primary / pathology*
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Pancreatic Ducts / metabolism
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Pancreatic Ducts / pathology*
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Pancreatic Neoplasms / complications
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Pancreatic Neoplasms / metabolism
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Pancreatic Neoplasms / pathology*
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Polymerase Chain Reaction
Substances
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Antibodies, Monoclonal
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DNA, Neoplasm
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Mucins
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Concanavalin A