Developmental evolution: Hox proteins ring the changes

Curr Biol. 2002 Apr 16;12(8):R291-3. doi: 10.1016/s0960-9822(02)00804-7.

Abstract

The evolution of body form is believed to involve changes in expression of developmental genes, largely through changes in cis-regulatory elements. Recent studies suggest that changes in the sequences of key developmental regulators, such as the Hox proteins, may also play an important role.

MeSH terms

  • Animals
  • Biological Evolution*
  • Crustacea / embryology
  • Crustacea / genetics
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Gene Expression Regulation, Developmental*
  • Homeodomain Proteins / genetics*
  • Homeodomain Proteins / metabolism*
  • Insecta / embryology
  • Insecta / genetics
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • Drosophila Proteins
  • Homeodomain Proteins
  • Transcription Factors
  • Ubx protein, Drosophila
  • distal-less protein, insect