The synthesis and biological activity of (165, 182, 189-S-carbamidomethylcysteine)-human growth hormone-(140-191)

Int J Pept Protein Res. 1975;7(6):495-501. doi: 10.1111/j.1399-3011.1975.tb02471.x.

Abstract

The peptide [165, 182, 189-S-carbamidomethylcysteine]-human growth hormone-(140-191) has been synthesized by the solid-phase method. The complement fixation, lactogenic and growth-promoting activities of the synthetic peptide were comparable to that of [165, 182, 189-S-carbamidomethylcysteine]-human growth hormone-(141-191) that was derived from the native hormone.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Columbidae
  • Complement Fixation Tests
  • Crop, Avian / metabolism
  • Growth Hormone / analogs & derivatives*
  • Growth Hormone / chemical synthesis
  • Growth Hormone / pharmacology
  • Peptide Fragments / chemical synthesis*
  • Peptide Fragments / pharmacology
  • Prolactin / metabolism
  • Rats
  • Tibia / growth & development

Substances

  • Peptide Fragments
  • Prolactin
  • Growth Hormone