Coronary artery disease does not occur in all the patients with acute myocardial infarction. Coronary artery diseases occurs in 97% of cases; in the other 3% of cases, myocardial infarction is caused by coronary spasm (40%, intracoronary thrombosis (60%) due to platelet hyperreactivity, peripartum thrombophilia or use of oral contraceptives. Myocardial infarction in young women is an infrequent event. Spontaneous coronary artery dissection is a rare cause of acute myocardial infarction that typically occurs during the peripartum period. A few cases of myocardial infarction in premenopausal women with no risk factors for coronary artery disease and normal coronary arteries have been reported. We describe 2 consecutive cases of acute myocardial infarction occurred in young, premenopausal women, without risk factors for cardiovascular diseases.