Kinetics of CD4 cells after discontinuation of antiretroviral therapy in patients with virological failure and a CD4 cell count greater than 500 cells/microl

AIDS. 2002 Jul 26;16(11):1551-4. doi: 10.1097/00002030-200207260-00013.

Abstract

After a median of 37 months on antiretroviral therapy, 16 patients were asked to discontinue treatment instead of changing it. After a median observation time of 10.5 months, most patients experienced a rapid and progressive decrease in their CD4 cell count, even without a high viral load rebound. This decline was unrelated to the CD4 cell count and HIV-RNA values at interruption, but was more profound in patients in whom the M184V mutation had disappeared after lamivudine discontinuation.

Publication types

  • Clinical Trial
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / therapeutic use
  • Antiretroviral Therapy, Highly Active*
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / pathology*
  • Female
  • Genotype
  • HIV / drug effects
  • HIV / genetics
  • HIV / isolation & purification
  • HIV / physiology
  • HIV Infections / drug therapy*
  • HIV Infections / immunology*
  • HIV Infections / virology
  • Humans
  • Lamivudine / administration & dosage
  • Lamivudine / therapeutic use
  • Male
  • Mutation / genetics
  • RNA, Viral / analysis
  • Time Factors
  • Viral Load

Substances

  • Anti-HIV Agents
  • RNA, Viral
  • Lamivudine