The adequacy of surgical treatment of melanoma patients is the most important milestone in the natural history of the disease, once the diagnosis has been confirmed. Surgery plays a fundamental role in the initial stages of the disease, ie, to remove the primary lesion and to excise accurately the locoregional metastases. On the contrary, the impact of a surgical indication to treat distant metastases has never been confirmed in a prospective study; thus, there are no standard guidelines and it represents a decision to be discussed with each individual patient.
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